0.9% Sodium Chloride infusion solution is a colourless or white crystal and is freely soluble in water and practically insoluble in anhydrous ethanol. 0.9% Sodium Chloride infusion solution preparations are clear, colourless, practically free from visible particles, sterile and non‐pyrogenic solutions. The concentrations of the active ingredients dissolved in a litre of Water for Injection are shown in the table in section 6.5. They do not contain an antimicrobial agent or added buffer. However, during the sterilisation step a small amount of hydrochloric acid may leach out resulting in a slightly acidic solution with a pH of 4.5 – 7.0.
Therapeutic indications 0.9% Sodium Chloride infusion solutions is indicated: As a vehicle for the administration of parenteral drugs Also utilised as an extracellular fluid replacement and in the management of metabolic alkalosis in the presence of fluid loss, and for restoring or maintaining the concentration of sodium and chloride ions. 4.2 Dose and method of administration 0.9% Sodium Chloride is for intravenous infusion. To be used as directed by the doctor.
Dosage, rate, and duration of administration are to be individualised and depend upon the indication for use, the patient’s age, weight, clinical condition, and concomitant treatment, and on the patient’s clinical and laboratory response to treatment. Parenteral drug products should be inspected visually for particulate matter and discolouration prior to administration whenever solution and container permit. The solution should be clear and free from particles. Do not administer unless solution is clear and seal is intact. Additives may be incompatible.
The instructions for use of the medication to be added and other relevant literature must be consulted. Consult with a pharmacist, if available. If in the informed judgment of the doctor, it is deemed advisable to introduce additives, use aseptic technique. NEW ZEALAND DATA SHEET 0.9% Sodium Chloride (AVIVA) Data Sheet 6 April 2017 Page 2 of 8 Baxter Healthcare Ltd When other electrolytes or medicines are added to this solution, the dosage and the infusion rate will also be dictated by the dose regimen of the additions. The product should be used for one patient on one occasion only. Any unused portion should be discarded. Directions for use of AVIVA plastic container
Warning. Do not connect flexible plastic containers in series in order to avoid air embolism due to possible residual air contained in the primary container. Pressurising intravenous solutions contained in flexible plastic containers to increase flow rates can result in air embolism if the residual air in the container is not fully evacuated prior to administration. Use of a vented intravenous administration set with the vent in the open position could result in air embolism. Vented intravenous administration sets with the vent in the open position should not be used with flexible plastic containers. To open Tear overwrap down side at slit and remove solution container. Some opacity of the plastic due to moisture absorption during the sterilisation process may be observed. This is normal and does not affect the solution quality or safety. The opacity will diminish gradually. Check for minute leaks by squeezing inner bag firmly. If leaks are found, discard the product as sterility may be impaired.